Enzyme Technologies for Pharmaceutical and Biotechnological...

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Preface
Genes related to human and animal health are being discovered at an ever-increas-
ing rate. As gene products, enzymes are being explored for their function and
application in a rapidly emerging field that has been termed functional genomics.
Enzyme Technologies for Pharmaceutical and Biotechnological Applications fills
a unique niche for prehensive account of certain important enzymes in
human and animal health. Readers can also gain important insights into enzyme
technologies in both the pharmaceutical and biotechnological industries. The pri-
mary aim of this book is to highlight how, what, and where enzymes have e
critically important or are rapidly emerging in these two overlapping and interde-
pendent industries.
As a state-of-the-art work on enzyme technologies, the book covers four
basic principles and applications in (1) antibiotic biosynthesis, (2) biocatalysis,
(3) modern screening/optimization, and (4) emerging new technologies. In Part
I, on biosynthesis, the emphasis is placed on both improvements in antibiotic
yield and ways to increase antibiotic structural diversity by modifications of the
biosynthetic pathways from diverse anisms. Here, the emphasis is on
using genes to deliver enzymes and to thereby perform metabolic engineering
including precursor-directed biosynthesis or mutasynthesis. The use of bi-
nant techniques to generate protein products that are unnatural to the microbial
world is also discussed, using specific examples of challenging problems in this
area.
Part II on biocatalysis, covers the direct application of enzymes as chemical
tools in manipulating small- to medium-sized pounds. Ma-
nipulation of the enzyme tools by ic engineering is described. Chapter 8
iii
iv Preface
discusses how a novel form of enzymes, cross-linked enzyme crystals (CLCs), are
especially useful as chemical catalysts. An example of a large-scale application of
these chemical tools brings the area into focus by l内容来自淘豆网www.taodocs.com转载请标明出处.